Products/Lung Cancer Cell Models

Pincer Lung Cell Model

Pincer Lung Cell Model


 

Product Family: Pincer Lung Cell Model
Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma, Invasive


Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma, Invasive
Age: 65-70
Sex: Female
Ethnicity: Caucasian
TNM Stage: T2aN0MX
Grade: IB
Treatment History: No prior treatment
Co-indications: Sensory loss in hands, Joint crepitus, Osteoarthritis, Seizure disorder, Lung nodule, Malignant neoplasm of the lung, Chronic obstructive pulmonary disease, Irritable bowel syndrome, Hypertension, Arthritis, Hypothyroidism, Depression, Hyperlipidemia
Medications: Metoprolol, Albuterol, Dicyclomine, Cyclobenzaprine, Fluticasone and salmeterol, Memantine HCl, Donepezil, Diphenhydramine, Tiotropium bromide monohydrate, Ropinirole
Country of Collection: United States
Year of Origin: 2016


MORPHOLOGY (2D)

 

MUTATIONS

 

Gene

Alteration

Frequency (%)

Exon

Result

PBRM1

A1073S

75

21

Mutated, Variant of Unknown Significance

BMPR1A

R443C

70

11

Mutated, Variant of Unknown Significance

TP53

N239S

47

7

Mutated, Presumed Pathogenic

RAF1

S259F

46

7

Mutated, Pathogenic

SMO

R709fs

12

12

Mutated, Variant of Unknown Significance

KDR (VEGFR2)

E730K

8

15

Mutated, Variant of Unknown Significance

 

PINCER DRUG RESPONSE

The Pincer Cell Model demonstrates sensitivity to Cisplatin and Etoposide, while showing resistance to Larotrectinib.

PINCER GROWTH CHARACTERISTICS

The growth curve of Pincer demonstrates consistent and rapid growth. Pincer cells grow continuously for 15+ passages.


CELL LINE PROTOCOL

See Passaging Protocol: Lung Cohort for detailed Protocol

STORAGE AND SAFETY

Storage and Stability: Store frozen in liquid nitrogen.

Quality Control: All lots are tested for consistent growth capabilities. See Certificate of Analysis for further details.

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Regular price
$985.00
Sale price
$985.00
Regular price
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Unit price
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SIZE
1 Million Cells per Cryovial

AVAILABILITY
In stock

PRODUCT CODE
CB-0304