The Jacket cell model originates from adenocarcinoma of the lung.

Product Family: Jacket Lung Cell Model
Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma of the lung

Disease Area:	Cancer
Tissue Type:	Lung
Clinical Diagnosis:	Adenocarcinoma of the lung
Age:	70-74
Sex:	Male
Ethnicity:	Caucasian
TNM Stage:	T2aN0MX
Grade:	IB
Co-indications:	N/A
Medications:	Ibuprofen
Country of Collection:	United States
Year of Origin:	2013

Gene Mutations

Gene	Alteration	Frequency (%)	Exon	Result
Androgen Receptor	F814V	100	6	Mutated, Presumed Pathogenic
KRAS	G12A	100	2	Mutated, Pathogenic
MSH6	G477S	32	4	Mutated, Variant of Unknown Significance
MUTYH	V493M	62	15	Mutated, Variant of Unknown Significance
TP53	S215G	100	6	Mutated, Presumed Pathogenic

Jacket Growth Characteristics

The historical growth curve of Jacket demonstrates consistent growth and highlights the lack of cell crisis.

STR Profile

AMEL: X
CSF1PO: 11
D13S317: 13
D16S539: 12
D18S51: 17
D21S11: 28
D3S1358: 15
D5S818: 12
D7S820: 8, 10
D8S1179: 12
FGA: 23
Penta D: 9
Penta E: 7
TH01: 9
TPOX: 11
vWA: 14

Immunohistochemistry

Tumor sample diagnosis was confirmed by histology and immunohistochemical detection of tumor markers.

Lineage Markers

Immunofluorescence detection of lineage markers confirm epithelial phenotype using pan-keratin with DAPI overlay.

Tumorsphere Formation

Spontaneous formation of tumorspheres under low-attachment conditions.

Additional Characteristics:

N/A

• Product Sheet
• Safety Data Sheet
• Protocols
• Certificate of Analysis

Storage and Stability: Store frozen in liquid nitrogen.

Care and Use Instructions: See protocol for further details

Quality Control: All lots are tested for microbial and viral contamination, cell line cross-contamination, mycoplasma, and consistent growth capabilities. See Certificate of Analysis for further details.