Products/Cancer Cell Models

Jacket Lung Cell Model
The Jacket cell model originates from adenocarcinoma of the lung.
General Information
The Jacket cell model originates from adenocarcinoma of the lung.
Product Family: Jacket Lung Cell Model
Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma of the lung
Clinical Profile
Disease Area: | Cancer |
Tissue Type: | Lung |
Clinical Diagnosis: | Adenocarcinoma of the lung |
Age: | 70-74 |
Sex: | Male |
Ethnicity: | Caucasian |
TNM Stage: | T2aN0MX |
Grade: | IB |
Co-indications: | N/A |
Medications: | Ibuprofen |
Country of Collection: | United States |
Year of Origin: | 2013 |
Characteristics
Gene Mutations
Gene | Alteration | Frequency (%) | Exon | Result |
Androgen Receptor | F814V | 100 | 6 | Mutated, Presumed Pathogenic |
KRAS | G12A | 100 | 2 | Mutated, Pathogenic |
MSH6 | G477S | 32 | 4 | Mutated, Variant of Unknown Significance |
MUTYH | V493M | 62 | 15 | Mutated, Variant of Unknown Significance |
TP53 | S215G | 100 | 6 | Mutated, Presumed Pathogenic |
Jacket Growth Characteristics
The historical growth curve of Jacket demonstrates consistent growth and highlights the lack of cell crisis.

STR Profile
AMEL: X
CSF1PO: 11
D13S317: 13
D16S539: 12
D18S51: 17
D21S11: 28
D3S1358: 15
D5S818: 12
D7S820: 8, 10
D8S1179: 12
FGA: 23
Penta D: 9
Penta E: 7
TH01: 9
TPOX: 11
vWA: 14
Immunohistochemistry
Tumor sample diagnosis was confirmed by histology and immunohistochemical detection of tumor markers.


Lineage Markers
Immunofluorescence detection of lineage markers confirm epithelial phenotype using pan-keratin with DAPI overlay.
Tumorsphere Formation
Spontaneous formation of tumorspheres under low-attachment conditions.


N/A
Documentation
Storage and Stability: Store frozen in liquid nitrogen.
Care and Use Instructions: See protocol for further details
Quality Control: All lots are tested for microbial and viral contamination, cell line cross-contamination, mycoplasma, and consistent growth capabilities. See Certificate of Analysis for further details.