Products/Cancer Cell Models

Pincer Lung Cell Model
General Information
Product Family: Pincer Lung Cell Model
Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma, Invasive
Clinical Profile
Disease Area: | Cancer |
Tissue Type: | Lung |
Clinical Diagnosis: | Adenocarcinoma, Invasive |
Age: | 65-70 |
Sex: | Female |
Ethnicity: | Caucasian |
TNM Stage: | T2aN0MX |
Grade: | IB |
Treatment History: | No prior treatment |
Co-indications: | Sensory loss in hands, Joint crepitus, Osteoarthritis, Seizure disorder, Lung nodule, Malignant neoplasm of the lung, Chronic obstructive pulmonary disease, Irritable bowel syndrome, Hypertension, Arthritis, Hypothyroidism, Depression, Hyperlipidemia |
Medications: | Metoprolol, Albuterol, Dicyclomine, Cyclobenzaprine, Fluticasone and salmeterol, Memantine HCl, Donepezil, Diphenhydramine, Tiotropium bromide monohydrate, Ropinirole |
Country of Collection: | United States |
Year of Origin: | 2016 |
Characteristics
MORPHOLOGY (2D)
MUTATIONS
Gene |
Alteration |
Frequency (%) |
Exon |
Result |
PBRM1 |
A1073S |
75 |
21 |
Mutated, Variant of Unknown Significance |
BMPR1A |
R443C |
70 |
11 |
Mutated, Variant of Unknown Significance |
TP53 |
N239S |
47 |
7 |
Mutated, Presumed Pathogenic |
RAF1 |
S259F |
46 |
7 |
Mutated, Pathogenic |
SMO |
R709fs |
12 |
12 |
Mutated, Variant of Unknown Significance |
KDR (VEGFR2) |
E730K |
8 |
15 |
Mutated, Variant of Unknown Significance |
PINCER DRUG RESPONSE
The Pincer Cell Model demonstrates sensitivity to Cisplatin and Etoposide, while showing resistance to Larotrectinib.
PINCER GROWTH CHARACTERISTICS
The growth curve of Pincer demonstrates consistent and rapid growth. Pincer cells grow continuously for 15+ passages.
Documentation
CELL LINE PROTOCOL
See Passaging Protocol: Lung Cohort for detailed Protocol
STORAGE AND SAFETY
Storage and Stability: Store frozen in liquid nitrogen.
Quality Control: All lots are tested for consistent growth capabilities. See Certificate of Analysis for further details.