Products/Cancer Cell Models
Throne Lung Cell Model
General Information
Product Family: Throne Lung Cell Model
Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma, Mixed Subtype
Clinical Profile
| Disease Area: | Cancer |
| Tissue Type: | Lung |
| Clinical Diagnosis: | Adenocarcinoma, Mixed Subtype |
| Age: | 80-85 |
| Sex: | Male |
| Ethnicity: | Unknown |
| TNM Stage: | T2aN2MX |
| Grade: | IIIA |
| Treatment History: | No prior treatment |
| Co-indications: | Right lung, non-small cell carcinoma, Melanoma of the nose, Knee replacement surgery, Tonsillectomy, Arthritis, Hypertension, Hypercholesterolemia |
| Medications: | Simvastatin, Omeprazole, Montelukast, Lisinopril, Hydrochlorothiazide, Acetaminophen and hydrocodone, Fluticasone nasal, Celecoxib, Finasteride, Doxazosin, Benzonatate, Ascorbic acid |
| Country of Collection: | United States |
| Year of Origin: | 2016 |
Characteristics
MORPHOLOGY (2D)
MUTATIONS
|
Gene |
Alteration |
Frequency (%) |
Exon |
Result |
|
POT1 |
G95C |
29 |
8 |
Mutated, Variant of Unknown Significance |
|
BRAF |
G464V |
26 |
11 |
Mutated, Pathogenic |
|
KRAS |
G13C |
26 |
2 |
Mutated, Pathogenic |
|
NF1 |
P678fs |
17 |
18 |
Mutated, Pathogenic |
|
POT1 |
E262X |
15 |
10 |
Mutated, Pathogenic |
THRONE DRUG RESPONSE
The Throne Cell Model demonstrates sensitivity to Cisplatin and Etoposide, while showing resistance to Larotrectinib.
THRONE GROWTH CHARACTERISTICS
The growth curve of Throne demonstrates consistent and rapid growth. Throne cells grow continuously for 15+ passages.
Documentation
CELL LINE PROTOCOL
See Passaging Protocol: Lung Cohort for detailed Protocol
STORAGE AND SAFETY
Storage and Stability: Store frozen in liquid nitrogen.
Quality Control: All lots are tested for consistent growth capabilities. See Certificate of Analysis for further details.